Nebulabio Offers Series of Drug Antibody References

• Drug Antibody & It's Structure

Drug Antibody, also known as therapeutic antibodies, are biologically engineered proteins designed to specifically target and bind to antigens, such as proteins or cells, involved in diseases. Antibody drugs can be used to treat a wide range of conditions, including cancers, autoimmune diseases, infectious diseases, and inflammatory disorders. Molecular structures are including following types:

(1) Fully murine monoclonal antibodies and human-murine chimeric antibodies, such as Muromonab-CD3 (a fully murine monoclonal antibody) and Rituximab (a human-murine chimeric antibody);

(2) Antibodies with a higher degree of humanization, such as Trastuzumab and Nimotuzumab;

(3) Fully humanized antibodies, which are entirely encoded by human genes and significantly reduce immunogenicity, such as Adalimumab;

(4) Other forms of molecules, including antibody fusion proteins, antibody-drug conjugates, bispecific antibodies, small molecule antibody fragments and nanobodies.

• Key Features of Antibody Drugs

Specificity: They bind to specific antigens with high precision, minimizing off-target effects.

Versatility: Antibody drugs can be engineered for various functions, such as blocking signaling pathways, recruiting immune cells, or delivering cytotoxic agents.

Diversity: They include monoclonal antibodies (mAbs), polyclonal antibodies, bispecific antibodies, antibody-drug conjugates (ADCs), and more.

Low Toxicity: Due to their specificity, they often have fewer side effects compared to traditional small-molecule drugs.

• Antibody drug reference standards play a critical role in drug development, production, and quality control

(1) Candidate Screening in Drug Development: Used to evaluate the activity, specificity, and affinity of candidate antibodies; Help understand the mechanism of action and biological functions of antibodies; Serve as a reference in antibody engineering to optimize structure and function.

(2) Production Process: Serve as a reference to optimize production conditions; Used to monitor consistency and stability during the production process.

(3) Quality Control: Assess the potency and activity of the drug; Detect impurities and degradation products; Evaluate the stability of the drug under different conditions.

(4) Pharmacodynamic Studies: Help determine safe and effective dosages; Serve as a reference to assess potential efficacy.

Nebula Biotechnology Co., Ltd. possesses an abundant collection of standard samples for drug antibody research, all of which are expressed through CHO or HEK293 cells. These samples boast a purity level exceeding 99%, with endotoxin levels lower than 1 EU/mg, making them suitable for various in vivo and in vitro validation tests.