Product Name:

NebuSelect™ Recombinant Human Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer, His-tag

Catalog#:

NBL-242424

Description:

NebuSelect™ Recombinant Human Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer, His-tag(Cat#NBL-242424) is expressed in HEK293 with His tag at the C-Terminus.It contains Leu32-Arg993(ITGA2B) acidic tail & GLy27-Asp718(ITGB3) basic tail.

Species:

Human

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 110.5 kDa (ITGA2B)&81.3 kDa (ITGB3). Due to glycosylation, the protein migrates to 95-115 kDa based on Bis-Tris PAGE result.

Target Name:

Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer; ITGA2B&ITGB3; ITGA2B; ITGB3

Target Information:

Glanzmann thrombasthenia (GT) is characterized by mucocutaneous bleeding due to platelets that fail to aggregate in response to physiologic stimuli. GT, a rare inherited disease, is caused by quantitative or qualitative deficiencies of αIIbβ3, an integrin receptor for adhesive proteins. Coded by the ITGA2B and ITGB3 genes, αIIbβ3 mediates platelet-to-platelet attachment, aggregation and clot retraction.

Amino Acid Sequence: 

Leu32-Arg993(ITGA2B) acidic tail & GLy27-Asp718(ITGB3) basic tail

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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