产品名称：Human Integrin a4b7 (ITGA4 & ITGB7) Antibody (Abrilumab, Research Use)
产品编号：NBR-0493
针对靶点：Integrin a4b7 (ITGA4 & ITGB7)
抗体药商品名：Abrilumab
抗体药描述：Abrilumab is a fully human monoclonal antibody directed against α4β7. Abrilumab selectively binds the α4β7 integrin heterodimer. Abrilumab can be used for the research of inflammatory bowel disease (IBD). 产品外观：Transparent Liquid
分子量：~150kDa
CAS：N/A
溶解度：Water; PBS, TBS Buffer等
表达系统：CHO Expressed
抗体亚型：Ab. Isotype - IgG

  Gene Name:  ITGA4 & ITGB7
Synonyms: CD49D
Target Description: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract.
Ensembl:  ENSG00000115232; ENSG00000139626
Uniprot:  P13612; P26010