Human IL-23 Antibody (Brazikumab, Research Use)

产品名称	Human IL-23 Antibody (Brazikumab, Research Use)
目录号	NBR-0749
别名	SGRF; IL-23a; P19;
外观	Transparent Liquid
分子量	150kDa
CAS	N/A
溶解度	Water, PBS, TBS Buffer,etc.
存储条件	Temp. -80℃
保存时间	see COA
备注1	CHO Expressed
备注2	Ab. Isotype - IgG

目录号	规格	价格	库存状态
NBR-0749-100UG	100ug	￥550	请咨询
NBR-0749-1MG	1mg	￥3500	请咨询
NBR-0749-5MG	5mg	￥7500	请咨询

【产品概况】

产品名称：Human IL-23 Antibody (Brazikumab, Research Use)
产品编号：NBR-0749
针对靶点：IL-23
抗体药商品名：Brazikumab
抗体药描述：Brazikumab (AMG 139) is a human IgG2 monoclonal antibody, selectively binds the p19 subunit of IL-23, with a KD of 0.138 nM for human IL-23. Brazikumab can be used for the research of Crohn's disease.

【产品参数】

产品外观：Transparent Liquid
分子量：~150kDa
CAS：N/A
溶解度：Water; PBS, TBS Buffer等
表达系统：CHO Expressed
抗体亚型：Ab. Isotype - IgG

【基因信息】

Gene Name: IL-23
Synonyms: SGRF; IL-23a; P19;
Target Description: Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4.
Ensembl: ENSG00000110944
Uniprot: Q9NPF7