Product Name:

NebuSelect™ Recombinant Human Noggin

Catalog#:

NBL-240471

Description:

NebuSelect™ Recombinant Human Noggin(Cat#NBL-240471) is expressed in CHO without tag.It contains Gln28-Cys232.

Species:

Human

Expression System:

CHO

Molecular Weight: 

The protein has a predicted MW of 23.05 kDa. Due to glycosylation, the protein migrates to 30-36 kDa based on Bis-Tris PAGE result.

Target Name:

Noggin; Noggin; NOG; SYM1; SYNS1

Target Information:

Noggin is an antagonist of bone morphogenetic proteins (BMP), being indispensable for certain developmental events.Noggin expression positively correlated with EGFR expression in both GC cell line models and The Cancer Genome Atlas human GC cohort. Targeting EGFR and its downstream pathways diminished cell proliferation which was promoted by Noggin. Noggin promotes the proliferation of GC cells by upregulating EGFR and enhancing a vicious circle formed by β‑catenin, EGFR, ERK and Akt.

Amino Acid Sequence: 

Gln28-Cys232

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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