Product Name:

NebuSelect™ Recombinant Human ANXA2, His-tag

Catalog#:

NBL-240663

Description:

NebuSelect™ Recombinant Human ANXA2, His-tag(Cat#NBL-240663) is expressed in E.coli with His tag at the N-terminus.It contains Ser2-Asp339.

Species:

Human

Expression System:

E.coli

Molecular Weight: 

The protein has a predicted MW of 39.6 kDa same as Bis-Tris PAGE result.

Target Name:

ANXA2; Chromobindin-8; Lipocortin II; PAP-IV; ANX2; ANX2L4; CAL1H; LPC2D; ANXA2; Annexin A2; Annexin II; LIP2PAP-IV; LPC2D; LPC2DP36; p36

Target Information:

ANXA2, highly expressed in invasive breast cancer cells, is closely related with poor prognosis, and acts as a molecular switch to EGFR activation. ANXA2 expression is inversely correlated with cell sensitivity to gefitinib. Knockdown of ANXA2 expression in MDA-MB-231 cells increased the gefitinib induced cell death. When ANXA2 was overexpressed in MCF7 cells, the gefitinib induced cell death was decreased. Furthermore, the phosphorylation of ANXA2 at Tyr23 is negatively correlated with the sensitivity of TNBC to gefitinib.

Amino Acid Sequence: 

Ser2-Asp339

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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