Product Name:

NebuSelect™ Recombinant Human Notch 3, His-tag

Catalog#:

NBL-240696

Description:

NebuSelect™ Recombinant Human Notch 3, His-tag(Cat#NBL-240696) is expressed in HEK293 with His tag at the C-Terminus.It contains Ala1378-Ser1640.

Species:

Human

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 30.18 kDa. Due to furin-like protease cleavage and glycosylation, the protein migrates to 27-30 kDa and 10-12 kDa based on Bis-Tris PAGE result.

Target Name:

Notch 3

Target Information:

Human Notch-3 is part of the Notch family of type I transmembrane glycoproteins involved in a number of early-event developmental processes. The extracellular domain of Notch receptors interact with the extracellular domain of transmembrane ligands Jagged, Delta, and Serrate expressed on the surface of a neighboring cell. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.

Amino Acid Sequence: 

Ala1378-Ser1640

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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