Product Name:

NebuSelect™ Recombinant Biotinylated Human Her2/ErbB2 Domain 4, Avi-His-tag

Catalog#:

NBL-240823

Description:

NebuSelect™ Recombinant Biotinylated Human Her2/ErbB2 Domain 4, Avi-His-tag(Cat#NBL-240823) is expressed in HEK293 with His tag and Avi tag at the C-Terminus.It contains Pro489-Cys630.

Species:

Human

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 18.5 kDa. Due to glycosylation, the protein migrates to 28-40 kDa based on Bis-Tris PAGE result.

Target Name:

Her2/ErbB2 Domain 4

Target Information:

ErbB2, also called Neu and Her2 (human epidermal growth factor receptor 2), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors.Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane.

Amino Acid Sequence: 

Pro489-Cys630

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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