Product Name:

NebuSelect™ Recombinant Cynomolgus LILRA4/CD85g, His-tag

Catalog#:

NBL-240846

Description:

NebuSelect™ Recombinant Cynomolgus LILRA4/CD85g, His-tag(Cat#NBL-240846) is expressed in HEK293 with His tag at the C-Terminus.It contains Glu24-Asn446.

Species:

Cynomolgus

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 47.7 kDa. Due to glycosylation, the protein migrates to 58-68 kDa based on Bis-Tris PAGE result.

Target Name:

LILRA4/CD85g; CD85g; ILT7; ILT-7; ILT7MGC129598; LILRA4; MGC129597

Target Information:

LILRA4, also known as ILT7 and CD85g, is an approximately 60-70 kDa variably glycosylated transmembrane protein that regulates immune cell activation. Mature human LILRA4 consists of a 423 amino acid (aa) extracellular domain (ECD) with four immunoglobulin-like domains, a 21 aa transmembrane segment, and a 32 aa cytoplasmic domain.LILRA4 function coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades.

Amino Acid Sequence: 

Glu24-Asn446

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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