Product Name:

NebuSelect™ Recombinant Human CD58, hFc-tag

Catalog#:

NBL-240886

Description:

NebuSelect™ Recombinant Human CD58, hFc-tag(Cat#NBL-240886) is expressed in HEK293 with hFc tag at the C-Terminus.It contains Phe29-Arg215.

Species:

Human

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 48.1 kDa. Due to glycosylation, the protein migrates to 65-75 kDa based on Bis-Tris PAGE result.

Target Name:

CD58; Lymphocyte function-associated antigen 3；Ag3；CD58；LFA3

Target Information:

Loss of CD58 is a common mechanism for tumor immune evasion in lymphoid malignancies. CD58 loss is known to occur due to both genetic and non-genetic causes; therefore, we hypothesized that restoring CD58 expression in lymphoma cells may be an effective treatment approach. EZH2 is involved in the epigenetic silencing of CD58 in lymphoma cells as a mechanism for tumor immune escape, and EZH2 inhibitors are able to restore epigenetically suppressed CD58 expression.

Amino Acid Sequence: 

Phe29-Arg215

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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