Product Name:

NebuSelect™ Recombinant Cynomolgus IL-23 alpha&IL-12 beta, His-tag

Catalog#:

NBL-240903

Description:

NebuSelect™ Recombinant Cynomolgus IL-23 alpha&IL-12 beta, His-tag(Cat#NBL-240903) is expressed in HEK293 with His tag at the N-terminus.It contains Val22-Pro189(IL-23 alpha) & Pro23-Leu328(IL-12 beta).

Species:

Cynomolgus

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 19.52 kDa (IL-23 alpha) and 34.76 kDa (IL-12 beta). Due to glycosylation, the protein migrates to 20-25 kDa (IL-23 alpha) and 40-50 kDa (IL-12 beta) based on Bis-Tris PAGE result.

Target Name:

IL-23 alpha&IL-12 beta

Target Information:

The interleukin (IL)-12 family of cytokines, including IL12 and IL 23, play an important role in driving aberrant Th1 and Th17 immune responses in patients with Crohn's disease (CD). Targeting this pathway has opened new avenues for therapeutic intervention. The balance of proinflammatory cytokines interleukin (IL)-12 and IL-23 plays a key role in shaping the development of antitumor or protumor immunity.

Amino Acid Sequence: 

Val22-Pro189(IL-23 alpha) & Pro23-Leu328(IL-12 beta)

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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