Product Name:

NebuSelect™ Recombinant Human PLAU/uPA (active form), His-tag

Catalog#:

NBL-240980

Description:

NebuSelect™ Recombinant Human PLAU/uPA (active form), His-tag(Cat#NBL-240980) is expressed in HEK293 with His tag at the C-Terminus.It contains Ser21-Leu431, which consists of two chains: Long chain A (Ser21-Phe177) and chain B (Ile179-Leu 431). The long chain A is further cleaved to yield a short chain A (Lys156-Phe 177) and N-Terminus fragment (Ser21-Lys155).

Species:

Human

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 17.9 kDa (long chain A), 29.2 kDa (chain B) and 15.3 kDa (N-terminal fragment). The protein migrates to 30-38 kDa (chain B) and 17 kDa (N-terminal fragment) based on Bis-Tris PAGE result.

Target Name:

PLAU/uPA; PLAU; Urokinase; ATF; UPA; URK; u-PA; BDPLT5; QPD

Target Information:

Plasminogen activator, urokinase (uPA) is a secreted serine protease, cleaving the sequence Cys-Pro-Gly-Arg560-Val561-Val-Gly-Gly-Cys in plasminogen to form plasmin. Dysregulation of PLAU is often accompanied by various cancers and PLAU inhibition could suppress tumor growth. Collectively, PLAU is necessary for tumor progression and can be a diagnostic and prognostic biomarker in HNSCC.

Amino Acid Sequence: 

Ser21-Leu431

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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