Product Name:

NebuSelect™ Recombinant Biotinylated Human PDGF R beta/CD140b, Avi-His-tag

Catalog#:

NBL-240981

Description:

NebuSelect™ Recombinant Biotinylated Human PDGF R beta/CD140b, Avi-His-tag(Cat#NBL-240981) is expressed in HEK293 with His tag and Avi tag at the C-Terminus.It contains Leu33-Phe530.

Species:

Human

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 59 kDa. Due to glycosylation, the protein migrates to 78-115 kDa based on Bis-Tris PAGE result.

Target Name:

PDGF R beta/CD140b; JTK12; PDGF R beta; PDGFR; PDGFR1; PDGFRB; CD140B; PDGFR-2; PDGFR-β

Target Information:

PDGF is a major serum mitogen that can exist as a homo or hetero-dimeric protein consisting of disulfide-linked PDGF-A and PDGF-B chains. The PDGF-AA,PDGF-BB and PDGF-AB isoforms have been shown to bind to two distinct cell surface PDGF receptors with different affinities. Where as PDGF R alpha binds all three PDGF isoforms with high affinity, PDGF R beta binds PDGF-BB only with high-affinity. PDGF R plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites.

Amino Acid Sequence: 

Leu33-Phe530

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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