Product Name:

NebuSelect™ Recombinant Biotinylated Human Notch 1, Avi-His-tag

Catalog#:

NBL-240987

Description:

NebuSelect™ Recombinant Biotinylated Human Notch 1, Avi-His-tag(Cat#NBL-240987) is expressed in HEK293 with His tag and Avi tag at the C-Terminus.It contains Ala19-Gln526.

Species:

Human

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 56.5 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result.

Target Name:

Notch 1; Notch-1; TAN1; NOTCH1; 9930111A19Rik; lin-12; Mis6; N1

Target Information:

Human Notch-1 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes.Notch-1 functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.

Amino Acid Sequence: 

Ala19-Gln526

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

To get more information, please contact us freely.