Product Name:

NebuSelect™ Recombinant Human KLRG1, hFc-tag

Catalog#:

NBL-240997

Description:

NebuSelect™ Recombinant Human KLRG1, hFc-tag(Cat#NBL-240997) is expressed in HEK293 with hFc tag at the N-Terminus.It contains Leu60-Phe195.

Species:

Human

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 42.8 kDa. Due to glycosylation, the protein migrates to 50-65 kDa based on Bis-Tris PAGE result.

Target Name:

KLRG1; KLRG1; CLEC15A; MAFA; MAFAL; 2F1; CLEC15AMAFA-LIKE; MGC13600

Target Information:

Immune homeostasis requires the tight, tissue-specific control of the different CD4 Foxp3 regulatory T (Treg) cell populations. The cadherin-binding inhibitory receptor killer cell lectin-like receptor G1 (KLRG1) is expressed by a subpopulation of Treg cells with GATA3 effector phenotype.Lack of KLRG1 on Treg cells conferred on them a competitive advantage in the gut, but not in lymphoid organs. Hence, although absence of KLRG1 is not enough to increase intestinal Treg cells in KLRG1 knockout mice, KLRG1 ligation reduces T-cell receptor signals and the competitive fitness of individual Treg cells in the intestine.

Amino Acid Sequence: 

Leu60-Phe195

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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