Product Name:

NebuSelect™ Recombinant Cynomolgus TLR3, His-tag

Catalog#:

NBL-241627

Description:

NebuSelect™ Recombinant Cynomolgus TLR3, His-tag(Cat#NBL-241627) is expressed in HEK293 with His tag at the C-Terminus.It contains Ser31-Glu711.

Species:

Cynomolgus

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 78.04 kDa. Due to glycosylation, the protein migrates to 95-115 kDa based on Bis-Tris PAGE result.

Target Name:

TLR3

Target Information:

TLR3 is expressed in the central nervous system (CNS), where it is required to control HSV-1, which spreads from the epithelium to the CNS via cranial nerves. TLR3 is also expressed in epithelial and dendritic cells, which apparently use TLR3-independent pathways to prevent further dissemination of HSV-1 and to provide resistance to other pathogens in TLR3-deficient patients. Human TLR3 appears to be redundant in host defense to most microbes but is vital for natural immunity to HSV-1 in the CNS, which suggests that neurotropic viruses have contributed to the evolutionary maintenance of TLR3.

Amino Acid Sequence: 

Ser31-Glu711

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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