Product Name:

NebuSelect™ Recombinant Cynomolgus TNFR2/CD120b/TNFRSF1B, His-tag

Catalog#:

NBL-242002

Description:

NebuSelect™ Recombinant Cynomolgus TNFR2/CD120b/TNFRSF1B, His-tag(Cat#NBL-242002) is expressed in HEK293 with His tag at the C-Terminus.It contains Leu23-Asp257.

Species:

Cynomolgus

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 26.1 kDa. Due to glycosylation, the protein migrates to 49-60 kDa based on Bis-Tris PAGE result.

Target Name:

TNFR2/CD120b/TNFRSF1B; CD120b; Etanercept; p75TBPII; p75TNFR; TNF RII; TNF-R2; TNF-R75; TNFR80; TNFRSF1B; TNFR2; TBPII; TNFBR; TNFR1B

Target Information:

Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa.Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

Amino Acid Sequence: 

Leu23-Asp257

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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