Product Name:

NebuSelect™ Recombinant Human SEMA4B, His-tag

Catalog#:

NBL-242130

Description:

NebuSelect™ Recombinant Human SEMA4B, His-tag(Cat#NBL-242130) is expressed in HEK293 with His tag at the C-Terminus.It contains Leu44-Glu717.

Species:

Human

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 75.8 kDa. Due to glycosylation, the protein migrates to 80-110 kDa based on Bis-Tris PAGE result.

Target Name:

SEMA4B; Semaphorin-4B; Semaphorin-C; SEMA4B; KIAA1745; SEMAC; MGC131831; SemC

Target Information:

Semaphorin 4B (SEMA4B) inhibits the invasion of non-small cell lung cancer (NSCLC) through PI3K-dependent suppression of MMP9 activation. SEMA4B may induce FoxO1 nuclear retention through suppressing PI3K/Akt signaling pathway, which subsequently inhibited cell growth through the direct nuclear target of FoxO1, p21. A role of SEMA4B in suppressing NSCLC growth, besides its role in inhibiting cell metastasis, and highlights SEMA4B as a promising therapeutic target for NSCLC.

Amino Acid Sequence: 

Leu44-Glu717

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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