Product Name:

NebuSelect™ Recombinant Mouse LGMN, His-tag

Catalog#:

NBL-242373

Description:

NebuSelect™ Recombinant Mouse LGMN, His-tag(Cat#NBL-242373) is expressed in HEK293 with His tag at the N-Terminus.It contains Val18-Tyr435.

Species:

Mouse

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 48.6 kDa. Due to glycosylation, the protein migrates to 55-60 kDa based on Bis-Tris PAGE result.

Target Name:

LGMN; Legumain; Prsc1; AEP; LGMN; LGMN1; AI746452; AU022324

Target Information:

Recently, functional studies have demonstrated that legumain (LGMN) cleaves both amyloid β-protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of Alzheimer's disease (AD). In single-variant association analysis, none of the common variants in LGMN were statistically significant. In gene-based analysis, the LGMN gene also showed no association with AD.

Amino Acid Sequence: 

Val18-Tyr435

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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