Product Name:

NebuSelect™ Recombinant Mouse Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer, His-tag

Catalog#:

NBL-242415

Description:

NebuSelect™ Recombinant Mouse Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer, His-tag(Cat#NBL-242415) is expressed in HEK293 with His tag at the C-Terminus.It contains Tyr27-Thr1129(ITGA2) acidic tail & Gln21-Asp728(ITGB1) basic tail.

Species:

Mouse

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 126.60 kDa(ITGA2)&82.80 kDa(ITGB1). Due to glycosylation, the protein migrates to 128-138 kDa(ITGA2)&105-115 kDa(ITGB1) based on Bis-Tris PAGE result.

Target Name:

Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer; ITGA2&ITGB1; ITGA2; ITGB1;

Target Information:

Integrin alpha 2 beta 1 is a positive regulator of collagenase (MMP-1) and collagen alpha 1(I) gene expression.HOS cells normally lacking alpha 2 beta 1 integrin were forced to express it, and this prevented the down-regulation in the levels of alpha 1 (I) collagen mRNA when cells were grown inside collagen gels. The data indicate that the level of MMP-1 expression is regulated by the collagen receptor alpha 2 beta 1 integrin.

Amino Acid Sequence: 

Tyr27-Thr1129(ITGA2) acidic tail & Gln21-Asp728(ITGB1) basic tail

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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