Product Name:

NebuSelect™ Recombinant Human IL-21R, hFc-tag

Catalog#:

NBL-242437

Description:

NebuSelect™ Recombinant Human IL-21R, hFc-tag(Cat#NBL-242437) is expressed in HEK293 with hFc tag at the C-Terminus.It contains Cys20-Pro236.

Species:

Human

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 51.8 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.

Target Name:

IL-21R; IL-21 receptor; IL-21R; CD360; NILR

Target Information:

IL-21 and IL-21R were highly expressed in the lesional skin and peripheral blood of psoriasis patients. IL-21 promoted CD4 T cells proliferation and Th17 cells differentiation and inhibiting Treg cells differentiation by upregulating RORγt expression and downregulating Foxp3 expression, with increased expression and secretion of IL-17A and IL-22.Microbial translocation and the associated immune activation during HIV-1 infection may lead to high expression levels of the IL-21R activation marker in RM B cells, a feature associated with increased apoptosis and a reduced number of these cells in the circulation.

Amino Acid Sequence: 

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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