Product Name:

NebuSelect™ Recombinant Mouse Glypican 1/GPC1, His-tag

Catalog#:

NBL-242560

Description:

NebuSelect™ Recombinant Mouse Glypican 1/GPC1, His-tag(Cat#NBL-242560) is expressed in HEK293 with His tag at the C-Terminus.It contains Asp24-Ser529.

Species:

Mouse

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 56.8 kDa. Due to glycosylation, the protein migrates to 65-68 kDa based on Bis-Tris PAGE result.

Target Name:

Glypican 1/GPC1; Glypican-1; FLJ38078; GPC1

Target Information:

CAR-T cells targeting glypican-1 (GPC1)-specific human and murine CAR-T cells generated from our original anti-human/mouse GPC1 antibody showed strong antitumor effects in xenogeneic and syngeneic mouse models, respectively. Importantly, the murine CAR-T cells enhanced endogenous T cell responses against a non-GPC1 tumor antigen through the mechanism of antigen-spreading and showed synergistic antitumor effects with anti-PD-1 antibody without any adverse effects in syngeneic models.

Amino Acid Sequence: 

Asp24-Ser529

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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