Product Name:

NebuSelect™ Recombinant Human EREG, hFc-tag

Catalog#:

NBL-242701

Description:

NebuSelect™ Recombinant Human EREG, hFc-tag(Cat#NBL-242701) is expressed in HEK293 with hFc tag at the N-Terminus.It contains Val63-Leu108.

Species:

Human

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 32.6 kDa. Due to glycosylation, the protein migrates to 37-42 kDa based on Bis-Tris PAGE result.

Target Name:

EREG; Proepiregulin; EPR; Epiregulin; EREG; ER

Target Information:

Epidermal growth factor receptor (EGFR) regulates many crucial cellular programs, with seven different activating ligands shaping cell signaling in distinct ways.EGFR ligands epiregulin (EREG) and epigen (EPGN) stabilize different dimeric conformations of the EGFR extracellular region. As a consequence, EREG or EPGN induce less stable EGFR dimers than EGF-making them partial agonists of EGFR dimerization. Unexpectedly, this weakened dimerization elicits more sustained EGFR signaling than seen with EGF, provoking responses in breast cancer cells associated with differentiation rather than proliferation.

Amino Acid Sequence: 

Val63-Leu108

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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