Product Name:

NebuSelect™ Recombinant SARS-COV-2 Spike RBD (N501Y), His-tag

Catalog#:

NBL-242796

Description:

NebuSelect™ Recombinant SARS-COV-2 Spike RBD (N501Y), His-tag(Cat#NBL-242796) is expressed in HEK293 with His tag at the C-Terminus.It contains Arg319-Phe541(N501Y).

Species:

SARS-COV-2

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 26.2 kDa. Due to glycosylation, the protein migrates to 36-40 kDa based on Bis-Tris PAGE result.

Target Name:

Spike RBD (N501Y); S protein RBD; S glycoprotein RBD; Spike protein RBD

Target Information:

The ongoing coronavirus disease 2019 (COVID-19) pandemic has prioritized the development of small-animal models for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The resulting mouse-adapted strain at passage 6 (called MASCp6) showed increased infectivity in mouse lung and led to interstitial pneumonia and inflammatory responses in both young and aged mice after intranasal inoculation. Deep sequencing revealed a panel of adaptive mutations potentially associated with the increased virulence. In particular, the N501Y mutation is located at the receptor binding domain (RBD) of the spike protein.

Amino Acid Sequence: 

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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