Product Name:

NebuSelect™ Recombinant Human BACE-1, hFc-tag

Catalog#:

NBL-243067

Description:

NebuSelect™ Recombinant Human BACE-1, hFc-tag(Cat#NBL-243067) is expressed in HEK293 with hFc tag at the C-Terminus.It contains Thr22-Thr457, which will be further processed into Thr22-Thr457(pro-form) & Glu46-Thr457(mature-form).

Species:

Human

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 75.2 kDa (pro-form) and 72.6 kDa (mature-form). Due to glycosylation, the protein migrates to 85-100 kDa based on Bis-Tris PAGE result.

Target Name:

BACE-1; Beta-secretase 1; ASP2; Asp 2; BACE1; BACE; FLJ90568; HSPC104; KIAA1149; Memapsin-2; BACE-1; EC 3.4.23; EC 3.4.23.46

Target Information:

The beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) initiates the generation of amyloid-β (Aβ), and the amyloid cascade leading to amyloid plaque deposition, neurodegeneration, and dementia in Alzheimer's disease (AD). Clinical failures of anti-Aβ therapies in dementia stages suggest that treatment has to start in the early, asymptomatic disease states.

Amino Acid Sequence: 

Thr22-Thr457

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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