Product Name: Human Integrin a4b7 (ITGA4 & ITGB7) Antibody (Vedolizumab, Research Use)
Catalog Number: NBR-0922
Target Name: Integrin a4b7 (ITGA4 & ITGB7)
Trade Name: Vedolizumab
Antibody Drug Description: Vedolizumab is a type of drug calleda monoclonal antibody. lt is used totreat inflammatory bowel disease(IBD), including ulcerative colitis andCrohn's disease. Vedolizumab is atargeted therapy that was designed tobe a gut-selective immunotherapy. Appearance: Transparent Liquid
Molecular Weight: ~150kDa
CAS：N/A
Solubility: Water; PBS, TBS Buffer etc.
Expression System: CHO Expressed
Isotype of Ab: Ab. Isotype - IgG

  Gene Name:  ITGA4 & ITGB7
Synonyms: CD49D
Target Description: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract.
Ensembl:  ENSG00000115232; ENSG00000139626
Uniprot:  P13612; P26010