Product Name: Human PVRIG Antibody (COM701, Research Use)
Catalog Number: NBR-0273
Target Name: PVRIG
Trade Name: COM701
Antibody Drug Description: COM701 is a novel 1st in-class immune checkpoint inhibitor. Its mechanism of action can lead to enhanced activation of T and natural killer (NK) cells. The reasoning behind combining COM701 with the anti-TIGIT therapy, BMS-986207, and the immune checkpoint inhibitor, nivolumab, is to block the DNAM axis, making treatment more tolerable. Appearance: Transparent Liquid
Molecular Weight: ~150kDa
CAS：N/A
Solubility: Water; PBS, TBS Buffer etc.
Expression System: CHO Expressed
Isotype of Ab: Ab. Isotype - IgG

  Gene Name: PVRI
Synonyms: GC7orf15; CD112R; MGC2463
Target Description: Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding. 
Ensembl: ENSG00000213413
Uniprot: Q6DKI7