【Introduction】
Product Name: Human RON Antibody (Narnatumab, Research Use)
Catalog Number: NBR-0276
Target Name: RON
Trade Name: Narnatumab
Antibody Drug Description: Narnatumab (IMC-RON8; LY3012219) is a neutralizing monoclonal antibody that blocks RON binding to its ligand, macrophage-stimulating protein (MSP).
【Description】
Appearance: Transparent Liquid
Molecular Weight: ~150kDa
CAS:N/A
Solubility: Water; PBS, TBS Buffer etc.
Expression System: CHO Expressed
Isotype of Ab: Ab. Isotype - IgG
【Gene Information】
Gene Name: RON
Synonyms: CD136; CDw136; PTK8; RON; SEA
Target Description: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules.
Ensembl: ENSG00000164078
Uniprot: Q04912