Product Name: Human RSPO3 Antibody (Rosmantuzumab, Research Use)
Catalog Number: NBR-0278
Target Name: RSPO3
Trade Name: Rosmantuzumab
Antibody Drug Description: Rosmantuzumab is a humanized monoclonal antibody against Human RSPO3 that can be potentially used in the treatment of Advanced Relapsed Tumor, Refractory Solid Tumors. Appearance: Transparent Liquid
Molecular Weight: ~150kDa
CAS：N/A
Solubility: Water; PBS, TBS Buffer etc.
Expression System: CHO Expressed
Isotype of Ab: Ab. Isotype - IgG

  Gene Name: RSPO3
Synonyms: FLJ14440; THSD2
Target Description: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes.
Ensembl: ENSG00000146374
Uniprot: Q9BXY4