Product Name: Human HtrA1 Antibody (FHTR2163, Research Use)
Catalog Number: NBR-0392
Target Name: HtrA1
Trade Name: FHTR2163
Antibody Drug Description: FHTR2163 is an antigen-binding fragment of a humanized immunoglobulin G1 monoclonal antibody directed against high-temperature requirement A serine peptidase 1 (HTRA1) that is being developed as a potential intravitreal (ITV) treatment for patients with geographic atrophy (GA), an advanced form of dry age-related macular degeneration. Appearance: Transparent Liquid
Molecular Weight: ~150kDa
CAS：N/A
Solubility: Water; PBS, TBS Buffer etc.
Expression System: CHO Expressed
Isotype of Ab: Ab. Isotype - IgG

  Gene Name: HtrA1
Synonyms: ARMD7; HtrA; IGFBP5-protease; PRSS11
Target Description: Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin.
Ensembl: ENSG00000166033
Uniprot: Q92743