Product Name: Human Notch3 Antibody (Tarextumab, Research Use)
Catalog Number: NBR-0436
Target Name: Notch3
Trade Name: Tarextumab
Antibody Drug Description: Tarextumab (formerly OMP-59R5) is a fully human monoclonal antibody targeting the Notch 2/3 receptors. It is being tested as a possible treatment for cancer. In January 2015, the US FDA granted orphan drug designation to tarextumab for the treatment of pancreatic cancer and lung cancer. Two early stage clinical trials have reported encouraging results. Appearance: Transparent Liquid
Molecular Weight: ~150kDa
CAS：N/A
Solubility: Water; PBS, TBS Buffer etc.
Expression System: CHO Expressed
Isotype of Ab: Ab. Isotype - IgG

  Gene Name: Notch3
Synonyms: CADASIL; CASIL
Target Description: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination 1.
Ensembl: ENSG00000074181
Uniprot: Q9UM47