Product Name: Human ERBB3 / HER3 Antibody (Barecetamab, Research Use)
Catalog Number: NBR-0674
Target Name: ERBB3 / HER3
Trade Name: Barecetamab
Antibody Drug Description: Barecetamab (ISU 104) is a highly potent, fully human anti-ErbB3 monoclonal antibody, binds potently and specifically to the NRG1 binding region of domain 3 of ErbB3, exhibits potent antitumorigenic activity. Barecetamab (ISU 104) inhibited ligand binding, ligand-dependent heterodimerization and phosphorylation, and induced the internalization of ErbB3. Appearance: Transparent Liquid
Molecular Weight: ~150kDa
CAS：N/A
Solubility: Water; PBS, TBS Buffer etc.
Expression System: CHO Expressed
Isotype of Ab: Ab. Isotype - IgG

  Gene Name: ERBB3
Synonyms: HER3; LCCS2
Target Description: This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation.
Ensembl: ENSG00000065361
Uniprot: P21860