Product Name: Human Hepcidin / HAMP Antibody (LY2787106, Research Use)
Catalog Number: NBR-0705
Target Name: Hepcidin / HAMP
Trade Name: LY2787106
Antibody Drug Description: LY2787106 is a fully humanized mAb with high affinity for human hepcidin. This phase 1 study evaluated the safety, PK/PD, and efficacy (effects on serum iron panel [iron, ferritin, transferrin saturation (TSAT), soluble transferrin receptor, reticulocyte hemoglobin], reticulocytosis, and hemoglobin [Hb]) of LY2787106 in cancer pts with anemia. Appearance: Transparent Liquid
Molecular Weight: ~150kDa
CAS：N/A
Solubility: Water; PBS, TBS Buffer etc.
Expression System: CHO Expressed
Isotype of Ab: Ab. Isotype - IgG

  Gene Name: HAMP 
Synonyms: HEPC; HFE2B; LEAP-1; LEAP1
Target Description: Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma.
Ensembl: ENSG00000105697
Uniprot: P81172