Product Name: Human IL-6 / IFNb2 Antibody (MEDI 5117, Research Use)
Catalog Number: NBR-0765
Target Name: IL-6 / IFNb2
Trade Name: MEDI 5117
Antibody Drug Description: MEDI5117 is a monoclonal antibody developed from a half-life–extended antibody using the YTE platform. MEDI5117 inhibited IL6 signaling and suppressed the growth of lung, breast, and ovarian tumor cells in vitro and in vivo with higher potency than siltuximab. Inhibition of tumor growth was significantly increased when MEDI5117 was used in combination with gefitinib, taxanes, or other chemotherapeutics. Appearance: Transparent Liquid
Molecular Weight: ~150kDa
CAS：N/A
Solubility: Water; PBS, TBS Buffer etc.
Expression System: CHO Expressed
Isotype of Ab: Ab. Isotype - IgG

  Gene Name: IL-6
Synonyms: IL-6; IFNB2; BSF2; HGF; HSF; BSF-2; CDF
Target Description: Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable).
Ensembl: ENSG00000136244
Uniprot:  P05231