Product Name: Human Integrin a2b1 (ITGA2 & ITGB1) Antibody (Vatelizumab, Research Use)
Catalog Number: NBR-0779
Target Name: Integrin a2b1 (ITGA2 & ITGB1)
Trade Name: Vatelizumab
Antibody Drug Description: Vatelizumab is a monoclonalantibody (a protein designed tointeract with a specific target) thattargets VLA-2 (or alpha2-beta1integrin). VLA-2 is a collagen-bindingmolecule expressed on activatedlymphocytes. lt has many potentiaroles in the immune system. Appearance: Transparent Liquid
Molecular Weight: ~150kDa
CAS：N/A
Solubility: Water; PBS, TBS Buffer etc.
Expression System: CHO Expressed
Isotype of Ab: Ab. Isotype - IgG

  Gene Name: ITGA2 & ITGB1
Synonyms: CD49B; CD29; FNRB; GPIIA; MDF2; MSK12
Target Description: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin.
Ensembl:  ENSG00000164171; ENSG00000150093
Uniprot:  P17301; P05556