Product Name: Human MUC18 / MCAM / CD146 Antibody (Imaprelimab, Research Use)
Catalog Number: NBR-0806
Target Name: MUC18 / MCAM / CD146
Trade Name: Imaprelimab
Antibody Drug Description: Imaprelimab (PRX-003) is an anti-MCAM mAb developed as a novel therapy for psoriasis. In patients with autoimmune diseases, a subset of MCAM+ve T cells (which have an effector memory T-helper 17 phenotype) produce high levels of pro-inflammatory IL-17. Appearance: Transparent Liquid
Molecular Weight: ~150kDa
CAS：N/A
Solubility: Water; PBS, TBS Buffer etc.
Expression System: CHO Expressed
Isotype of Ab: Ab. Isotype - IgG

  Gene Name:  MCAM
Synonyms: CD146; HEMCAM; MelCAM; METCAM; MUC18
Target Description: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. 
Ensembl: ENSG00000076706
Uniprot: P43121